Topics
2025年9月22日、23日、髙橋教授はNeuroGlobal programの国際交流の一環として、ドイツ・マインツのライプニッツレジリエンス研究所を訪問 […]
Subcortical and cortical mechanisms in primate during active vision […]
Predictive coding during Natural Self-Motion: Implications for Perception & Action […]
Our Research
眼を通して脳へ
眼球運動の背後にある回路を辿り、脳機能を解読する
絶えず変化する世界をうまく生き抜くには、脳は知覚を行動へと変換しなければなりません。感覚入力の大部分は視覚情報ですが、私たちは自分の眼球運動について意識することはほとんどありません。
私たちの研究室では、脳がどのように視覚情報を選択し、その情報を正確な眼球運動に変換するかを研究しています。毎日何千回も繰り返されるこれらの急速な眼球運動は、脳の意思決定プロセスを垣間見るための貴重な情報源となります。そのスピードと一見単純な動作にもかかわらず、実際には複数の脳領域に分布する精密に調整された神経回路に依存しています。
ヒトと動物の両モデルにおいて、行動、認知、神経生理学のアプローチを組み合わせることで、脳がどのように視覚情報と行動を結び付けているかを解明することを目指しています。私たちの研究は、脳のダイナミクスへの理解を深め、医学、人工知能、神経疾患の研究に新たな情報をもたらします。
Our Team
講師 Chen Chih-Yang
Junior Associate Professor
医学博士 安藤 貴弘
Researcher
清水 暁陽
(M6, Science Tokyo)
Student
岡藤 健人 (M4)
Student
桑原 大河 (M4)
Student
土屋 浩子
Secretary
Selected Publications
- Takahashi M, Sugiuchi Y, Shinoda Y. Brainstem neural circuits for triggering vertical saccades and fixation. J. Neuroscience 44(1): e1657232023, 2024.
- Veale R, Takahashi M. Pathways for naturalistic looking behavior in primate. II. Superior Colliculus Integrates Parallel Top-down and Bottom-up Inputs. (Forefront Review) Neuroscience 545: 86-110, 2024.
- Takahashi M, Veale R. Pathways for naturalistic looking behavior in primate I: Behavioral characteristics and brainstem circuits. (Forefront Review) Neuroscience 532: 133-163, 2023.
- Takahashi M, Sugiuchi Y, Na J, Shinoda Y. Brainstem neural circuits triggering saccades and fixation. J. Neuroscience, 42: 789-803, 2022.
- Takahashi M, Sugiuchi Y, Shinoda Y. Neural substrates for generation of oblique saccades. Equilibrium Research 81: 67-78, 2022.
- Takahashi M, Shinoda Y. Neural circuits of inputs and outputs of the cerebellar cortex and nuclei. Neuroscience 462: 70-88, 2021.
- Takahashi M, Shinoda Y. Fastigial Nucleus Input/Output related to Motor Control. Cerebellum as a CNS Hub (eds. H. Mizusawa and S. Kakei) pp. 199-237, Springer Nature Switzerland, 2021.
- Takahashi M, Morphological and electrophysiological characteristics of the commissural system in the superior colliculi for control of eye movements. Prog. Brain Res. 249: 105-115, 2019.
- Shinoda Y, Takahashi M, Sugiuchi Y. Brainstem neural circuits for fixation and generation of saccadic eye movements. Prog. Brain Res. 249: 95-104, 2019.
- Takahashi M, Shinoda Y. Brain stem neural circuits for horizontal and vertical saccade systems and their frame of reference. (Forefront Review) Neuroscience 392: 281-328, 2018.
- Luo Y, Fujita F, Nedelescu H, Biswas MS, Sato C, Ying S, Takahashi M, Akita K, Higashi T, Aoki I, Sugihara I. Lobular homology in cerebellar hemispheres of humans, non-human primates and rodents: a structural, axon tracing and molecular expression analysis. Brain Structure and Function 222: 2449-2472, 2017.
- Takahashi M, Sugiuchi Y, Shinoda Y. Convergent synaptic inputs from the caudal fastigial nucleus and the superior colliculus onto pontine and pontomedullary reticulospinal neurons. J. Neurophysiology 111: 849-867, 2014.
- Sugiuchi Y, Takahashi M, Shinoda Y. Input-output organization of inhibitory neurons in the interstitial nucleus of Cajal projecting to the contralateral trochlear and oculomotor nucleus. J. Neurophysiology 110: 640-657, 2013.
- Shinoda Y, Sugiuchi Y, Takahashi M, Izawa Y. Neural substrate for suppression of omnipause neurons at the onset of saccades. Ann. N.Y. Acad. Sci. 1233: 100-106, 2011.
- Takahashi M, Sugiuchi Y, Shinoda Y. Topographic organization of excitatory and inhibitory commissural connections in the superior colliculi and their functional roles in saccade generation. J. Neurophysiology 104: 3146-3167, 2010.
- Shinoda Y, Sugiuchi Y, Izawa Y, Takahashi M. Neural circuits for triggering saccades in the brainstem. Prog. Brain Res. 171: 79-85, 2008.
- Sugiuchi Y, Izawa Y, Takahashi M, Na J, Shinoda Y. Controversy on “Fixation Zone” of the Superior Colliculus. Neuro-Ophthalmology 31: 147-155, 2007.
- Takahashi M, Sugiuchi Y, Shinoda Y. Commissural mirror- symmetric excitation and reciprocal inhibition between the two superior colliculi and their roles in vertical and horizontal eye movements. J. Neurophysiology 98:2664-2682, 2007.
- Takahashi M, Sugiuchi Y, Izawa Y, Shinoda Y. Commissural excitation and inhibition by the superior colliculus in tectoreticular neurons projecting to omnipause neuron and inhibitory burst neuron regions. J. Neurophysiology 94:1707-1726, 2005.
- Takahashi M, Sugiuchi Y, Izawa Y, Shinoda Y. Synaptic inputs and their pathways from fixation and saccade zones of the SC to inhibitory burst neurons. Ann. N.Y. Acad. Sci. 1039: 209-219, 2005.
- Sugiuchi Y, Izawa Y, Takahashi M, Na J, Shinoda Y. Physiological characterization of synaptic inputs to inhibitory burst neurons from the rostral and caudal SC. J. Neurophysiology 93: 697-712, 2005.
Contact
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